SitemapFull page index of Advertising Regulation in Japan (Promotional Material Review) and Artificial Intelligence
All chapters, parts, and articles on this site, listed hierarchically. Crawler sitemap available at /sitemap.xml.
Yakugai History (History of Drug Disasters)
The historical events that built modern drug regulation — from Sulfanilamide (1937) to Thalidomide (1957-1962).
- Drug Disaster History (chapter top)
- 1 Elixir Sulfanilamide — The Starting Point of Modern Drug Regulation
- 2 Thalidomide 1957–1962 / Worldwide — The Disaster That Built Modern Drug Regulation
- 3 DES (Diethylstilbestrol) — A Drug Disaster Across Generations
- 4 The SMON Incident — Birth of Japan's Post-Marketing Surveillance
- 5 HIV-Tainted Blood Products in Japan — Systemic Non-Action and Its Aftermath
- 6 The Drug-induced Hepatitis C Incident — Records Held but Not Used
- 7 Creutzfeldt–Jakob Disease from Cadaveric Dura Mater
- 8 Iressa (Gefitinib) — A "Miracle Drug" and Interstitial Pneumonia
- 9 Vioxx (Rofecoxib) — The Ethics of Data Disclosure
- 10 The Opioid Crisis — A Drug Disaster Not Yet Over
Ethics
Medical, corporate, and professional ethics — centered on the protection of patient rights.
- Ethics (chapter top)
- 1 Pharmaceutical Corporate Ethics — Holding the Tension Between Profit and Medicine
- 2 From Nuremberg to Helsinki — The Events and Documents That Built Bioethics
- 3 Medical Ethics — Four Principles and the Three at the Bedside
- 4 If My Wife Were the Patient — Reading Patient Rights as a Stakeholder
- 5 Personal Professional Ethics — When Rules and Judgment Diverge
- 6 What is Ethics, in the First Place? — The "wrong-coffee" incident at Cafe Socrates
- 7 Research Ethics: History and Present — How Participant Protection Was Institutionalized
- 8 Publication Ethics: History and Present — The Conscience Mechanism Science Built for Itself
Compliance
The specificity of the life-related industry, and the architecture of social trust.
- Compliance (chapter top)
- 1 Starting from "Life-Related Industry" — Reading the Walls Between Us and Patients
- 2 Social Trust — The Condition for This Industry to Exist
- 3 Corporate Philosophy — Putting Trust into Words
- 4 Policies — From Principle to Direction
- 5 SOPs — From Policy to Procedure
- 6 Ethics and Norms — The Undocumented Territory
Ad Regulations
Pharmaceutical advertising regulation centered on Pharmaceutical Act §§66-68.
- Advertising Regulation (chapter top)
- 01 Pharmaceutical Act §§66-68 and the Two Cases That Shaped the Norms
- 02 The Suspecting Eye — Reading Risk Beyond the Rules
- 03 Advertising Appropriateness Standards — Operationalizing Article 66
- 04 MSA Guidelines — 4-chapter commentary
- 05 MSA Q&A commentary — 80 questions across 4 MHLW compendia
- 06 JPMA Code of Practice
- 07 JPMA Material-Creation Guide — 5-level commentary
Material Review — 8-part / 29-volume series
The work of judging promotional materials, walked through: map → international lens → mindset → solitude → risk → reasoning → per-medium practice → culture.
Production Quality ManagementNEW
Quality assurance for client-commissioned materials — full regulatory conformance / AI review / QC-QA SOPs / four-signature delivery.
Material Requester (Manager)'s ResponsibilitiesNEW
The intermediate gate before vendor deliverables get forwarded to internal material review.
Developing Material Creators ── Learning from Past IncidentsNEW
Drawn from 7 years and 186 deviation cases, the recurring errors in material creation structured into nine categories, read from primary sources.
- Developing Material Creators (Index)
- Overview ── The Whole Picture
- Learning from Past Incidents (Series Index)
- 01 ── Data Misuse and Manipulation That Risk Factual Misrepresentation
- 02 ── Selective Data Extraction, Manipulation, and Presentation
- 03 ── Claims Without Evidence / Unreliable Data
- 04 ── Presenting Unapproved Indications and Dosage Regimens
- 05 ── Exaggerated Claims
- 06 ── Efficacy-Only Promotion / Safety Information Neglect
- 07 ── Disparagement of Competing Products
- 08 ── COI Non-Disclosure
- 09 ── Other Improper Sales Practices
Developing Material Creators ── Inside the Creator ── The Psychology Behind DeviationsNEW
How well-intentioned creators drift toward deviation under pressure — confirmation bias, motivated reasoning, local rationalization, omission, externalized responsibility — across ten chapters of psychology and organizational structure.
- Inside the Creator ── The Psychology Behind Deviations (Series Index)
- 01 ── A Map of Pressure — How Good Intentions Bend
- 02 ── The Creed Trap — "I Want to Help Patients" as the Entry Point
- 03 ── Conclusion First, Data Second — Motivated Reasoning
- 04 ── "Just One Slide" — Local Rationalization
- 05 ── The Choice Not to Speak — The Sin of Omission
- 06 ── Structures That Let You Blame Someone Else — Externalizing Responsibility
- 07 ── The Gravity of Numbers — Quotas and the Psychology of Incentives
- 08 ── The Anxiety of Competition — How Panic Becomes Disparagement
- 09 ── The Silent Organization — Conformity Pressure, Hollow Audits, and the Self That Won't Disclose
- 10 ── Redesigning Pressure — Individual Psychology and Organizational Systems
Developing Material Creators ── As We Should Be ── Ten Convictions for Material CreatorsNEW
Who a material creator should be — ten convictions articulating the professional backbone that prevents deviation: standing as an evidence steward rather than a salesperson, responsibility for the reader's mental image, a conscience led by data, signing the whole document, and a duty to present efficacy and safety on equal footing. Ten chapters.
- As We Should Be ── Ten Convictions for Material Creators (Series Index)
- 01 ── Scientific Evidence Steward — I Am Not a Salesperson
- 02 ── Taking Responsibility for the Reader's Mental Image
- 03 ── The Conscience That Doubts Conclusions — Led by Data
- 04 ── Sign the Whole — Not Just One Slide
- 05 ── Duty to Tell — Efficacy and Safety on Equal Footing
- 06 ── Own It — Don't Hide Behind "The Physician Decides"
- 07 ── The Right Distance from Numbers — Quotas as Constraints, Not Goals
- 08 ── Respect for Competitors — Fair Play Builds Trust
- 09 ── Staying Open — Disclosing Limitations, Uncertainty, and Conflicts of Interest on Your Own
- 10 ── Embedding Conscience into the Organization's Systems — From the Individual to the Organization, Made Visible
Reviewer Development ── The Compound Eye of ReviewNEW
Reading deviations that clause-matching alone cannot catch, from the standpoints of patients, families, lawyers, regulators, and society. Ten chapters move between the rule-eye that reads the rules closely and the recipient-eye, and show how to hold both together.
- The Compound Eye of Review (Series Index)
- 01 ── Two Ways of Seeing — Why Reviewers Need Both the Rule-Eye and the Recipient-Eye
- 02 ── Micro-Level Reading — Knowing the Rules, and Why They Exist
- 03 ── Someone Is on the Other Side of My Reviewing Eye — Perspective-Taking as a Way of Using Knowledge
- 04 ── The Patient's Eye — I Am the One Who Takes This Drug
- 05 ── The Family's Eye — Spouse, Parent, Adult Child at the Bedside
- 06 ── The Lawyer's Eye — Can This Material Survive Cross-Examination?
- 07 ── The Regulator's Eye — Reading Your Own Materials from the Inspection Standpoint
- 08 ── Imagining the Front-Page Headline — The Most Critical Eye: Media and Society
- 09 ── Integrating Lenses — What Premortem and Bird's-Eye View Add to Material Review
- 10 ── Making the bird's-eye view a habit — reading past failures as a mirror
Perspectives ── The Four Layers of Management ── 5 series × 10 episodes = 50 vol
The manager's view broken into five layers — capital (the capitalist), governance (the board), execution (the executives), risk, and the foreign-pharma president — reading what material review means in the language of management.
- The Four Layers of Management (hub)
- The Capitalist's View — Investment and Profit (index)
- The Capitalist's View — Investment and Profit — Vol. 1
- The Capitalist's View — Investment and Profit — Vol. 2
- The Capitalist's View — Investment and Profit — Vol. 3
- The Capitalist's View — Investment and Profit — Vol. 4
- The Capitalist's View — Investment and Profit — Vol. 5
- The Capitalist's View — Investment and Profit — Vol. 6
- The Capitalist's View — Investment and Profit — Vol. 7
- The Capitalist's View — Investment and Profit — Vol. 8
- The Capitalist's View — Investment and Profit — Vol. 9
- The Capitalist's View — Investment and Profit — Vol. 10
- The Board's View — Corporate Governance (index)
- The Board's View — Corporate Governance — Vol. 1
- The Board's View — Corporate Governance — Vol. 2
- The Board's View — Corporate Governance — Vol. 3
- The Board's View — Corporate Governance — Vol. 4
- The Board's View — Corporate Governance — Vol. 5
- The Board's View — Corporate Governance — Vol. 6
- The Board's View — Corporate Governance — Vol. 7
- The Board's View — Corporate Governance — Vol. 8
- The Board's View — Corporate Governance — Vol. 9
- The Board's View — Corporate Governance — Vol. 10
- The Executives' View — Running the Business (index)
- The Executives' View — Running the Business — Vol. 1
- The Executives' View — Running the Business — Vol. 2
- The Executives' View — Running the Business — Vol. 3
- The Executives' View — Running the Business — Vol. 4
- The Executives' View — Running the Business — Vol. 5
- The Executives' View — Running the Business — Vol. 6
- The Executives' View — Running the Business — Vol. 7
- The Executives' View — Running the Business — Vol. 8
- The Executives' View — Running the Business — Vol. 9
- The Executives' View — Running the Business — Vol. 10
- Management and Risk (index)
- Management and Risk — Vol. 1
- Management and Risk — Vol. 2
- Management and Risk — Vol. 3
- Management and Risk — Vol. 4
- Management and Risk — Vol. 5
- Management and Risk — Vol. 6
- Management and Risk — Vol. 7
- Management and Risk — Vol. 8
- Management and Risk — Vol. 9
- Management and Risk — Vol. 10
Perspectives ── Metacognition (Introspection) ── 3 series × 10 episodes = 30 vol
"Looking at the self" — introspection and awareness series. From Freud / Jung / Adler to Baumeister / Bandura / Neff.
Perspectives ── Self-Transformation ── 2 series × 10 episodes = 20 vol
"Changing the inner self" — transformation and confidence series. Acceptance, change, and self-efficacy.
Perspectives ── Communication ── 10 episodes
Dialogue with others, correctness vs. reach, feedback delivery, the option of silence.
AI Courses (Basics)
Practical fundamentals for using AI in daily work.
AI Courses (Applied)
AI in marketing, programming, and healthcare.
AI and Emerging Technology
Industry models, companies, R&D, regulatory dynamics.
- AI and Emerging Technology (index)
- AI-driven shifts in social structure (2024-2028)
- Novartis CEO joins Anthropic's Board
- AI drug discovery, the last year
- AI clinics in the Middle East and China
- Microsoft's 7 AI models and Scout
- AI Index 2026
- Anthropic Mythos
- China AI+ strategy
- NVIDIA RTX Spark
- Agentic AI 2026
- Humanoid AI
AI and the Pharmaceutical IndustryNEW
Daily record of pharmaceutical AI funding, deals and deployments across 15 business functions, from drug discovery to finance.
- AI and the Pharmaceutical Industry (daily archive)
- Weekly aggregates
- 🧬 Drug Discovery
- 🧪 Clinical Development
- 📑 CTD / Regulatory Submission
- 🩺 GCP Operations
- 📘 ICH Guidelines & AI
- 🛡️ Pharmacovigilance / GVP
- 📊 RWE / Evidence Generation
- 🎓 Medical Affairs
- 💼 Sales
- 📣 Marketing
- 🚚 Distribution / Supply Chain
- ✅ GQP / Quality Assurance
- 👥 Human Resources
- 💴 Finance & Accounting
- 🏛️ Enterprise AI Platform & Governance
AI Economy & FinanceNEW
Twice-daily reports on AI and the economy, and AI and finance, in the same format as AI Daily News.
AI Daily Update VideoNEW
A fifteen-minute explainer on the day's AI, with full transcript and sources.
- AI Daily Update Video (index)
- 2026-09-19 ── The day AI hacked itself
- 2026-09-18 ── The day a maker disclosed its own faults
- 2026-09-17 ── The day AI firms began attacking each other
- 2026-09-16 ── The day three rivals joined hands on safety
- 2026-09-15 ── The day the slowdown argument entered politics
- 2026-09-14 ── The Day an AI Developer Admitted the Lie
- 2026-09-13 ── The Day Caution Got a Price Tag
- 2026-09-12 ── The Day AI Leaders Talked About Slowing Down
Microsoft Copilot Know-howNEW
Sourced know-how for Microsoft 365 Copilot: 10 app pages and 6 cross-cutting topics.
- Microsoft Copilot Know-how (index)
- Word — Draft, summarize, rewrite (14)
- Excel — Analysis, formulas, charts (9)
- PowerPoint — Slides from documents, summaries (8)
- Outlook — Summaries, replies, scheduling (9)
- Teams — Meeting and chat recaps (9)
- OneNote — Note summaries, to-dos (7)
- Loop — What remains, what to use instead (7)
- SharePoint / OneDrive — Summarize and compare files (10)
- Copilot Chat — Work IQ, Researcher, saved prompts (10)
- Notebooks / Pages — Gather references and ask (8)
- Choosing Between Opus and GPT — Choosing a model (16)
- Building AI Agents with Agent Builder — Build with Agent Builder (16)
- Operating AI Agents — Admin, billing, audit (14)
- Working with OneDrive — Storage and file references (6)
- Grounding Copilot in Your Stored Content — Permissions, labels, oversharing (10)
- Concept Search and Insight across OneDrive Documents — Search by meaning, check understanding (22)
- Update log
Microsoft Copilot AdvancedNEW
Combining Microsoft 365 apps with Python, Microsoft Graph and automation: 10 app pages and 6 thinking-and-method pages, with code, permissions, test results and sources.
- Microsoft Copilot Advanced (index)
- Excel × Python — Python in Excel, pandas, openpyxl (8)
- Word × Python — Extract and check with python-docx (7)
- PowerPoint × Python — Batch checks with python-pptx (7)
- Outlook × Python — Tally mail and events via Graph (7)
- Teams × Python — Notifications, messages, bots (7)
- SharePoint / OneDrive × Python — Drives, lists, delta queries (8)
- Document Search × Python — BM25, embeddings, hybrid search (10)
- Agents × Python — Adding Python to agents (7)
- Code Execution in Copilot — Code execution and checking (6)
- Power Automate × Python — Flows with Python (6)
- End-to-End Manual — End to end, one worked example (0)
- Computational Thinking — Decompose, abstract, verify (0)
- From Instructions to Code — Prompt patterns for code (6)
- Choosing Where Code Runs — Choosing a runtime (6)
- Authentication, Permissions and Governance — Auth, least privilege, audit (8)
- Workflow Recipes — Document workflow recipes (5)
- Microsoft Copilot Advanced update log
AI LiteracyNEW
Eleven stages of working with AI, from a first spark to running it, in 10 series of 10 episodes. One a day.
- Contents (10 series × 10 episodes)
- S1-01 A Spark Can Go to AI as a Question
- S1-02 The Three-Agent Team in the First Recorded Week
- S1-03 Start a Spark by Finding What Already Exists
- S1-04 Define What You Are Collecting Before AI Collects It
- S1-05 Let AI Inventory Your Own Expertise
- S1-06 Reviewing Only What Is Written Will Not Reduce Errors
- S1-07 Redefine Reviewer Variance as Viewpoint Diversity